Scientists find "mother" of all skin cells
Scientists find "mother" of all skin cells
Scientists find "mother" of all skin cells
(Reuters) - Scientists have found the "mother," or origin, of all skin cells and christmas wreathsay their discovery could dramatically improve skin treatments #xfor victims of serious wounds and burns.
Hans Clevers and a team of Dutch and Swedish researchers conducted a study in mice and found that the stem cell that gives produces all the different cells of the skin actually lives in hair follicles.
The findings, which they say will translate for human use, mean it may be possible to harness these stem cells to help with wound repair or skin transplants for burns victims, they said in a study in the Science journal on Thursday.
"This is the mother of all the stem cells in the skin -- it makes all the other stem cells," Clevers, of the Royal Netherlands Academy of Arts and Sciences in Utrecht, told Reuters in a telephone interview.
"The same stem cells exist in humans, we can see them, and thechristmas wreath promise is that these cells are probably going to be much better than anything we have had to date at making new skin."
The skin has three different populations of cells -- hair follicles, moisturizing sebaceous glands, and the tissue in between, known as the interfollicular epidermis. Stem cells are original cells, or drivers, from which all human cells develop.
Scientists had previously thought that stem cells in each of these three skin populations were capable of producing their own cell type, but until now, a "mother" stem cell which produces all three types had not been found.
Clevers' team found that a group of stem cells that live in hair follicles and which have high levels of a gene called Lgr6 are the original epidermal stem cells.
In tests on mice with wounds,samurai swords, they found that Lrg6 cells around the wound drove new skin growth and repaired the skin.
Scientists are already able to grow new skin in laboratories #xusing tissue from existing skin cells from patients who have been badly burned, but thechristmas wreath new skin is often brittle, dry and does not have hair -- making it look unusual.
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